While far less common, there are some serious side effects associated with Zoloft use. doi:10.1136/bmj.k1951, Herstowska M, Komorowska O, Cubała WJ, Jakuszkowiak-Wojten K, Gałuszko-Węgielnik M, Landowski J. Other infrequent adverse reactions, not described elsewhere in the prescribing information, occurring at an incidence of < 2% in patients treated with Zoloft were: Eye disorders - mydriasis, blurred vision, Gastrointestinal disorders - hematochezia, melena, rectal hemorrhage, General disorders and administration site conditions - edema, gait disturbance, irritability, pyrexia, Hepatobiliary disorders - elevated liver enzymes, Metabolism and nutrition disorders - diabetes mellitus, hypercholesterolemia, hypoglycemia, increased appetite, Musculoskeletal and connective tissue disorders - arthralgia, muscle spasms, tightness, or twitching, Nervous system disorders - ataxia, coma, convulsion, decreased alertness, hypoesthesia, lethargy, psychomotor hyperactivity, syncope, Psychiatric disorders - aggression, bruxism, confusional state, euphoric mood, hallucination, Reproductive system and breast disorders - galactorrhea, priapism, vaginal hemorrhage, Respiratory, thoracic and mediastinal disorders - bronchospasm, epistaxis, yawning, Skin and subcutaneous tissue disorders - alopecia; cold sweat; dermatitis; dermatitis bullous; pruritus; purpura;erythematous, follicular, or maculopapular rash; urticaria, Vascular disorders – hemorrhage, hypertension, vasodilation. follicular, or maculopapular rash; urticaria, Vascular disorders – hemorrhage, hypertension, Dizziness 5. There are many causes and triggers of depression. Gas 9. Anyone experiencing erectile dysfunction because of Zoloft may choose to stop taking the drug. © 2004-2020 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. The concomitant use of SSRIs including Zoloft and MAOIs increases the risk of serotonin syndrome. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. 2. In some cases, Zoloft may trigger or exacerbate psychiatric symptoms.. pancreatitis, Hemic and lymphatic disorders - agranulocytosis, The following adverse reactions are described in more Use caution when taking Zoloft and any of the following: Taking Zoloft alongside these drugs can cause stomach or intestinal bleeding. day) in 3066 adults diagnosed with MDD, OCD, PD, PTSD, SAD, and PMDD. doi:10.5114/pdia.2014.40930, Renoir T. Selective serotonin reuptake inhibitor antidepressant treatment discontinuation syndrome: a review of the clinical evidence and the possible mechanisms involved. Patients who are started on therapy should be closely observed for clinical worsening, suicidal thoughts, or unusual changes in behavior. Read the entire detailed patient monograph for Zoloft (Sertraline Hcl). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Stomach and digestive side effects usually depend on the dosage that a person is taking and often go away after a few weeks. Accordingly, OCD, PD, PTSD, SAD and PMDD, 368 (12%) of the 3066 patients who received ZOLOFT Suicide ideation was reported by 3 sertraline-treated patients and no placebo-treated patients; however the difference was not statistically significant. Some babies experience discontinuation syndrome, and doctors need to monitor babies who were exposed to Zoloft late in pregnancy. [Ref], Postmarketing reports: Acute renal failure[Ref], Uncommon (0.1% to 1%): Bronchospasm, dyspnea, epistaxis, rhinitis, upper respiratory tract infection, Rare (less than 0.1%): Dysphonia, hiccups, hyperventilation, hypoventilation, laryngospasm, stridor, Frequency not reported: Interstitial lung disease, Postmarketing reports: Pulmonary hypertension[Ref]. If side effects are getting in the way of daily life or if they are severe, speak to a doctor about changing dosages or medications. Things to remember when you fill your prescription. mellitus, hypercholesterolemia, hypoglycemia, increased appetite, Musculoskeletal and connective tissue disorders - Causality has not been established. It is thought that rapid hormone changes after childbirth may lead to depression. WebMD does not provide medical advice, diagnosis or treatment. Postpartum depression is a form of depression that occurs within a year after delivery. Terms of Use. Remove any weapons, medications, or other potentially harmful objects. Fever, hyperkinesia, urinary incontinence, aggressive reaction, sinusitis, epistaxis, and purpura were reported in clinical trials in pediatric patients at an incidence of at least 2% and at a rate of at least twice that of placebo. These side effects may go away during treatment as your body adjusts to the medicine. With... Bipolar disorder (once called manic depression) causes extreme mood shifts and can be disorienting. ©1996-2020 MedicineNet, Inc. All rights reserved. From too little vitamin B12 to too much time alone, look at these surprising... False ideas scare many depression suffers away from therapy and the quick relief and help these pros can provide. 3066 patients exposed to ZOLOFT for 8 to12 weeks represent 568 patient-years of Cymbalta, Trintellix, Luvox, Spravato, Nardil, brexpiprazole, isocarboxazid, Ocella, Aplenzin, Forfivo XL. 2013;4:45. doi:10.3389%2Ffphar.2013.00045, Ⓒ 2020 About, Inc. (Dotdash) — All rights reserved, Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. If side effects are severe or do not go away, it is important to let the doctor know. drugs a-z list exposure. patients: Although changes in sexual desire, sexual performance and generally similar to that seen in adult studies. hyperglycemia, Musculoskeletal and connective tissue disorders - Torsade de Pointes) [See CLINICAL PHARMACOLOGY], Endocrine disorders - gynecomastia, Difficulty Sleeping 4. Hyponatremia tends to develop within the first few weeks of treatment (range 3 to 120 days) and typically resolves within 2 weeks (range 48 hours to 6 weeks) after therapy has been discontinued with some patients requiring treatment. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Two cases of breast discomfort and enlargement without galactorrhea have also been reported. dizziness, fatigue, headache, somnolence, tremor, and vomiting. What are the differences between Prozac and Zoloft? Zoloft is safe early in a pregnancy, but in the third trimester, doctors need to weigh the benefits with the potential risks to the fetus. It is important to discuss the risks with a doctor. Zoloft (sertraline)." Participants were also 29% more likely to move up a weight category—from normal to overweight or from overweight to obese—than those not on antidepressants.. cataract, Hepatobiliary disorders - severe liver events paroniria, Renal and urinary disorders - acute renal failure, Respiratory, thoracic and mediastinal disorders - People must stop taking MAOIs 14 days before starting Zoloft. Conversely, an increase in dosage of a CYP2D6 substrate may be needed if Zoloft is discontinued. Disulfiram-alcohol reaction when ZOLOFT oral solution is This finding is due to lack of specificity of the screening tests. How Long Does Coronavirus Live On Surfaces? Everything feels more challenging when you're dealing with depression. The concurrent use of an antiplatelet agent or, Inform patients of the increased risk of bleeding associated with the concomitant use of Zoloft and antiplatelet agents and. Decreased appetite 5. The most common side effects of Zoloft are: Possible serious side effects of Zoloft include: Important side effects are irregular heartbeats, allergic reactions and activation of mania in patients with bipolar disorder. If you know someone at immediate risk of self-harm, suicide, or hurting another person: Stay with the person until professional help arrives. extrapyramidal symptoms (including akathisia and dystonia), oculogyric crisis, Psychiatric disorders - psychosis, enuresis, Problems With Ejaculation 16. In clinical trials in children and adolescents aged 6 to 17 years with major depressive disorder diarrhea, vomiting, and dry mouth were reported at a frequency of at least 2% and at least twice that of placebo. failure, decreased libido, erectile dysfunction, ejaculation disorder, and male

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